**Figure 1**
Examples of two-dimensional diffraction intensity patterns simulated for lysozyme by assuming the wavelength of the incident X-rays = 1 Å and the intensity *I*_{i} = 5 × 10^{21} photons pulse^{−1} mm^{−2}. In (*b*), the theoretically expected mean number of diffracted photons arriving at a Shannon pixel is shown. In (*a*), the number of photons is an integer, chosen according to the Poisson distribution having the theoretically expected mean value as its mean. For this assumed intensity, the mean count of 0.1 photon is observed at 2 Å. In this figure both the abscissa and ordinate show detector coordinates in the sense that they are proportional to coordinates on a flat detector on which the surface of an Ewald sphere is radially projected from its centre (central azimuthal projection). |