Acta Crystallographica Section B

Structural Science

Volume 62, Part 3 (June 2006)

research papers

Acta Cryst. (2006). B62, 498-505 [ doi:10.1107/S0108768106012018 ]

17 salts of ephedrine: crystal structures and packing analysis

E. A. Collier, R. J. Davey, S. N. Black and R. J. Roberts

Abstract: The structures of two neutral and 17 salt forms of the base (1R, 2S)-(-)-ephedrine are reported. These structures are discussed in the light of the conformers of the ephedrine moiety, the existence of bilayers and the structure determining role of the counterions. Overall, most of the salt structures are essentially derived from the observed packing of the neutral base and are dominated by the amphiphilic nature of the ephedrine molecular structure. In a few cases the size and hydrophobicity of the counterion disrupts this behaviour.

Keywords: packing analysis; counterion; molecular salts; pharmaceuticals.


	Structure factor file (CIF format) (947.1 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEACETsup2.hkl ] Contains datablock EPHEACET

	Structure factor file (CIF format) (129.8 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEADIPsup3.hkl ] Contains datablock EPHEADIP

	Structure factor file (CIF format) (443.9 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEBESYsup4.hkl ] Contains datablock EPHEBESY

	Structure factor file (CIF format) (875.4 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEEDISsup5.hkl ] Contains datablock EPHEEDIS

	Structure factor file (CIF format) (61.4 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEESYLsup6.hkl ] Contains datablock EPHEESYL

	Structure factor file (CIF format) (360.0 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEGLYCsup7.hkl ] Contains datablock EPHEGLYC

	Structure factor file (CIF format) (765.8 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEHCLsup8.hkl ] Contains datablock EPHEHCL

	Structure factor file (CIF format) (426.4 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEHEMIsup9.hkl ] Contains datablock EPHEHEMI

	Structure factor file (CIF format) (556.3 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEMALAsup10.hkl ] Supplementary material

	Structure factor file (CIF format) (929.7 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEMALEsup11.hkl ] Supplementary material

	Structure factor file (CIF format) (328.9 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEMALOsup12.hkl ] Supplementary material

	Structure factor file (CIF format) (258.9 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEMESYsup13.hkl ] Supplementary material

	Structure factor file (CIF format) (233.5 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHENITRsup14.hkl ] Supplementary material

	Structure factor file (CIF format) (331.9 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEPHOSsup15.hkl ] Supplementary material

	Structure factor file (CIF format) (856.1 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEBISUsup16.hkl ] Supplementary material

	Structure factor file (CIF format) (60.1 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHETART1sup17.hkl ] Supplementary material

	Structure factor file (CIF format) (547.8 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHETART3sup18.hkl ] Supplementary material

	Structure factor file (CIF format) (490.2 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHETOSYsup19.hkl ] Supplementary material

	Structure factor file (CIF format) (671.6 kbytes) [ doi:10.1107/S0108768106012018/bk5025EPHEsup20.hkl ] Supplementary material

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