Acta Crystallographica Section B

Structural Science, Crystal Engineering and Materials

Volume 70, Part 1 (February 2014)

crystal engineering

Acta Cryst. (2014). B70, 54-62    [ doi:10.1107/S2052520613026711 ]

Solvates of the antifungal drug griseofulvin: structural, thermochemical and conformational analysis

S. Aitipamula, P. S. Chow and R. B. H. Tan

Abstract: Four solvates of an antifungal drug, griseofulvin (GF), were discovered. All the solvates were characterized by differential scanning calorimetry, thermogravimetric analysis, and their crystal structures were determined by single-crystal X-ray diffraction. The solvents that form the solvates are acetonitrile, nitromethane and nitroethane (2:1 and 1:1). It was found that all the solvates lose the solvent molecules from the crystal lattice between 343 and 383 K, and that the melting point of the desolvated materials matched the melting point of the solvent-free GF (493 K). The conformation of the GF molecule in solvent-free form was found to be significantly different from the conformations found in the solvates. Solution stability studies revealed that the GF-acetonitrile solvate transforms to GF and that GF-nitroethane (1:1) solvate transforms to GF-nitroethane (2:1) solvate. On the other hand, GF-nitromethane and GF-nitroethane (2:1) solvates were found to be stable in solution. Our results highlight the importance of the co-crystallization technique in the pharmaceutical drug development; it not only expands the solid form diversity but also creates new avenues for unraveling novel solvates.

Keywords: griseofulvin; solvates; conformational analysis; thermal analysis.

pdfdisplay filedownload file

Portable Document Format (PDF) file
[ doi:10.1107/S2052520613026711/zb5031sup6.pdf ]
This material contains a comparison of 1H NMR spectra of the nitroethane solvates, an ORTEP plot and a packing diagram of GF-nitroethane (1:1) solvate, and PXRD patterns and SEM images of the desolvated crystals

txtdisplay filedownload file

Text file (22.4 kbytes)
[ doi:10.1107/S2052520613026711/zb5031sup7.txt ]
CIF file for the crystal structure of GF-nitroethane (1:1) with guest molecule

txtdisplay filedownload file

Text file (231.6 kbytes)
[ doi:10.1107/S2052520613026711/zb5031sup8.txt ]
Structure factors file for the crystal structure of GF-nitroethane (1:1) with guest molecule


To open or display or play some files, you may need to set your browser up to use the appropriate software. See the full list of file types for an explanation of the different file types and their related mime types and, where available links to sites from where the appropriate software may be obtained.

The download button will force most browsers to prompt for a file name to store the data on your hard disk.

Where possible, images are represented by thumbnails.

 bibliographic record in  format

  Find reference:   Volume   Page   
  Search:     From   to      Advanced search

Copyright © International Union of Crystallography
IUCr Webmaster