Acta Crystallographica Section C

Crystal Structure Communications

Volume 57, Part 11 (November 2001)

Acta Cryst. (2001). C57, 1330-1332 [doi:10.1107/S0108270101013506]

Pyrazolidine-3,5-dione angiotensin-II receptor antagonists

C. Cauvin, B. Le Bourdonnec, B. Norberg, J.-P. Hénichart and F. Durant

Abstract: The crystal structures of three angiotensin-II receptor antagonists involving different spacer groups (CO, CONH and NHCO) between the aryl rings are presented, namely 2-{4-[(3-butyl-1,4-dioxo-2,3-diazaspiro[4.4]non-2-yl)methyl]benzoyl}benzoic acid, C₂₆H₂₈N₂O₅, (I), 2-{4-[(3-butyl-1,4-dioxo-2,3-diazaspiro[4.4]non-2-yl)methyl]benzamido}benzoic acid, C₂₆H₂₉N₃O₅, (II), and 2-{4-[(3-butyl-1,4-dioxo-2,3-diazaspiro[4.4]non-2-yl)methyl]anilinocarbonyl}benzoic acid monohydrate, C₂₆H₂₉N₃O₅·H₂O, (III). The aryl rings of (II) are almost coplanar, in contrast with compounds (I) and (III). The conformation of (II) is induced by an intramolecular N-HO hydrogen bond between the amide and carboxylic acid groups.

Formula: C₂₆H₂₈N₂O₅, C₂₆H₂₉N₃O₅ and C₂₆H₂₉N₃O₅·H₂O

Online 13 November 2001


	Structure factor file (CIF format) (221.0 kbytes) Contains datablock I

	Structure factor file (CIF format) (233.1 kbytes) Contains datablock II

	Structure factor file (CIF format) (236.9 kbytes) Contains datablock III

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