Acta Crystallographica Section C

Crystal Structure Communications

Volume 58, Part 7 (July 2002)

Acta Cryst. (2002). C58, o399-o401 [doi:10.1107/S0108270102009241]

1-Substituted derivatives of 2-aryl-5-oxopyrrolidine-2-carboxylic acid

H. Karapetyan, R. Tamazyan, A. Martirosyan, V. Hovhannesyan and S. Gasparyan

Abstract: The structures of two potential anti-human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTI), namely 1-benzyl-5-oxo-2-phenylpyrrolidine-2-carboxamide, C₁₈H₁₈N₂O₂, (III), and 2-(4-isopropoxyphenyl)-5-oxo-1-(4-tolyl)pyrrolidine-2-carbonitrile, C₂₁H₂₂N₂O₂, (IV), have been investigated by X-ray diffraction, confirming the butterfly-like conformation of both compounds. The pyrrolidine ring is in an envelope conformation in (III) and a half-chair conformation in (IV). Two intermolecular N-HO hydrogen bonds are present in the crystal structure of (III), with NO distances of 2.995 (2) and 2.927 (2) Å.

Formula: C₁₈H₁₈N₂O₂ and C₂₁H₂₂N₂O₂

Online 20 June 2002


	Structure factor file (CIF format) (216.1 kbytes) Contains datablock III

	Structure factor file (CIF format) (226.4 kbytes) Contains datablock IV

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