Acta Crystallographica Section C

Crystal Structure Communications

Volume 58, Part 8 (August 2002)

Acta Cryst. (2002). C58, o521-o524 [doi:10.1107/S0108270102012386]

[Hydroxy(aryl)methylene]diphosphonic acids, a class of drugs in bone pathology treatments, crystallize as head-to-head dimers

M. Lecouvey, C. Barbey, A. Navaza, A. Neuman and T. Prangé

Abstract: Two [hydroxy(aryl)methylene]diphosphonic acids have been crystallized as dimers. The first compound, [hydroxy(phenyl)methylene]diphosphonic acid monohydrate, C₇H₁₀O₇P₂·H₂O, crystallizes in the non-centrosymmetric space group P2₁, with the two enantiomers related by a non-crystallographic centre of inversion, while the second compound, [hydroxy(4-nitrophenyl)methylene]diphosphonic acid tetrahydrofuran disolvate, C₇H₉NO₉P₂·2C₄H₈O, crystallizes in the centrosymmetric space group P2₁/c and uses the centre of symmetry to form the same dimer.

Formula: C₇H₁₀O₇P₂·H₂O and C₇H₉NO₉P₂·2C₄H₈O

Online 31 July 2002


	Structure factor file (CIF format) (168.2 kbytes) Contains datablock IIIa

	Structure factor file (CIF format) (183.1 kbytes) Contains datablock IIIb

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