Acta Crystallographica Section C

Crystal Structure Communications

Volume 59, Part 8 (August 2003)

Acta Cryst. (2003). C59, o422-o425 [doi:10.1107/S0108270103012332]

2-(2-Naphthyloxy)acetate derivatives. I. A new class of antiamnesic agents

S. Thamotharan, V. Parthasarathi, R. Malik, D. P. Jindal, P. Piplani and A. Linden

Abstract: The title compounds 1-(2-naphthyloxymethylcarbonyl)piperidine, C₁₇H₁₉NO₂, (I), and 3-methyl-1-(2-naphthyloxymethylcarbonyl)piperidine, C₁₈H₂₁NO₂, (II), are potential antiamnesics. In (II), the methyl-substituted piperidine ring is disordered over two conformations. The piperidine ring has a chair conformation in both compounds. In (I), the molecules are linked by weak intermolecular C-HO interactions to give networks represented by C(4), C(6) and R₄⁴(18) graph-set motifs, while in (II), weak intermolecular C-HO interactions generate R₁²(5), C(4) and C(7) graph-set motifs. The dihedral angle between the naphthalene moiety and the piperidine ring is 33.83 (7)° in (I), while it is 31.78 (11) and 19.38 (19)° for the major and minor conformations, respectively, in (II).

Formula: C₁₇H₁₉NO₂ and C₁₈H₂₁NO₂

Online 12 July 2003


	Structure factor file (CIF format) (66.3 kbytes) Contains datablock I

	Structure factor file (CIF format) (68.6 kbytes) Contains datablock II

Notes:

To open or display or play some files, you may need to set your browser up to use the appropriate software. See the full list of file types for an explanation of the different file types and their related mime types and, where available links to sites from where the appropriate software may be obtained.

The download button will force most browsers to prompt for a file name to store the data on your hard disk.

Where possible, images are represented by thumbnails.