Acta Crystallographica Section C

Crystal Structure Communications

Volume 59, Part 11 (November 2003)

gg1180 scheme

Acta Cryst. (2003). C59, o629-o633 [doi:10.1107/S0108270103021401]

Four cytotoxic N4-substituted thiosemicarbazones derived from 2-hydroxynaphthalene-1-carboxaldehyde

P. V. Bernhardt, L. M. Caldwell, D. B. Lovejoy and D. R. Richardson

Abstract: The X-ray crystal structures are reported of four novel and potentially O,N,S-tridentate donor ligands that demonstrate antitumour activity. These ligands are 1-[(4-methylthiosemicarbazono)methyl]-2-naphthol, C₁₃H₁₃N₃OS, (III), 1-[(4-ethylthiosemicarbazono)methyl]-2-naphthol, C₁₄H₁₅N₃OS, (IV), 1-[(4-phenylthiosemicarbazono)methyl]-2-naphthol, C₁₈H₁₅N₃OS, (V), and 1-[(4,4-dimethylthiosemicarbazono)methyl]-2-naphthol dimethyl sulfoxide solvate, C₁₄H₁₅N₃OS·C₂H₆OS, (VI). These chelators are N4-substituted thiosemicarbazones, each based on the same parent aldehyde, namely 2-zhydroxynaphthalene-1-carboxaldehyde isonicotinoylhydrazone. Conformational variations within this series are discussed in relation to the optimum conformation for metal-ion binding.

Formula: C₁₃H₁₃N₃OS, C₁₄H₁₅N₃OS, C₁₈H₁₅N₃OS and C₁₄H₁₅N₃OS·C₂H₆OS

Online 22 October 2003


	Structure factor file (CIF format) (57.4 kbytes) Contains datablock III

	Structure factor file (CIF format) (116.1 kbytes) Contains datablock IV

	Structure factor file (CIF format) (132.2 kbytes) Contains datablock V

	Structure factor file (CIF format) (147.5 kbytes) Contains datablock VI

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