Acta Crystallographica Section C

Crystal Structure Communications

Volume 59, Part 12 (December 2003)

Acta Cryst. (2003). C59, o724-o726 [doi:10.1107/S010827010302506X]

Two azasteroidal [3,2-c]pyrazole derivatives: 2'-(p-fluorophenyl)-4-azapyrazolo[4',3':2,3]-5-androstan-17-yl acetate and 2'-(p-fluorophenyl)-4-azapyrazolo[4',3':2,3]-5-androstan-17-ol

S. Thamotharan, V. Parthasarathi, R. Gupta, D. P. Jindal and A. Linden

Abstract: In both the title aza-steroids, 2'-(p-fluorophenyl)-4-azapyrazolo[4',3':2,3]-5 [alpha] -androstan-17 [beta] -yl acetate, C₂₇H₃₄FN₃O₂, (I), and 2'-(p-fluorophenyl)-4-azapyrazolo[4',3':2,3]-5 [alpha] -androstan-17 [beta] -ol, C₂₅H₃₂FN₃O, (II), the tetrahydropyridine ring adopts a half-chair conformation and is considerably strained as a consequence of the presence of the fused planar pyrazole ring. In both compounds, both cyclohexane rings have chair conformations, while the cyclopentane ring has an envelope conformation. All the rings of the steroid nucleus are trans fused. In (I), intermolecular N-HO, C-HF, C-HO and C-HN interactions are observed in the solid state, while intermolecular N-HO and O-HN hydrogen bonds are observed in (II).

Formula: C₂₇H₃₄FN₃O₂ and C₂₅H₃₂FN₃O

Online 30 November 2003


	Structure factor file (CIF format) (183.7 kbytes) Contains datablock I

	Structure factor file (CIF format) (134.5 kbytes) Contains datablock II

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