Acta Crystallographica Section C

Crystal Structure Communications

Volume 60, Part 5 (May 2004)

av1168 scheme

Acta Cryst. (2004). C60, o377-o380 [doi:10.1107/S0108270104004342]

Vindoline and 16-demethoxyvindoline: two catharanthus-derived alkaloids

J. Ruszkowska, R. Chrobak, J. K. Maurin and Z. Czarnocki

Abstract: Vindoline, C₂₅H₃₂N₂O₆, and 16-demethoxyvindoline, C₂₄H₃₀N₂O₅, both of which are naturally occurring biologically active products derived from plants, are important as possible starting materials for the synthesis of valuable anticancer antibiotics, viz. vincristine and vinblastine, and other pharmaceuticals. The vindoline framework consists of two five- and three six-membered condensed rings. One of the six-membered rings adopts a boat conformation, one adopts a sofa conformation and the third is planar. Both five-membered rings have envelope structures. The intramolecular hydrogen bonds present in the structures are characteristic of vinca alkaloids.

Formula: C₂₅H₃₂N₂O₆ and C₂₄H₃₀N₂O₅

Online 30 April 2004


	Structure factor file (CIF format) (208.4 kbytes) Contains datablock I

	Structure factor file (CIF format) (212.3 kbytes) Contains datablock 2

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