Acta Crystallographica Section C

Crystal Structure Communications

Volume 60, Part 9 (September 2004)

dn1055 scheme

Acta Cryst. (2004). C60, o648-o652 [doi:10.1107/S0108270104016117]

1-[4-(Methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole derivatives

C. Charlier, B. Norberg, L. Goossens, J.-P. Hénichart and F. Durant

Abstract: Three related compounds containing a pyrazole moiety with vicinal phenyl rings featuring a methylsulfonyl substituent are described, namely 3-methyl-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole, C₁₇H₁₆N₂O₂S, ethyl 1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole-3-carboxylate, C₁₉H₁₈N₂O₄S, and 1-[4-(methylsulfonyl)phenyl]-3-[3-(morpholino)phenoxymethyl]-5-phenyl-1H-pyrazole, C₂₇H₂₇N₃O₄S. The design of these compounds was based on celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, in order to study the influence of various substituents on COX-2 and 5-lipoxygenase (5-LOX) inhibition.

Formula: C₁₇H₁₆N₂O₂S, C₁₉H₁₈N₂O₄S and C₂₇H₂₇N₃O₄S

Online 11 August 2004


	Structure factor file (CIF format) (309.5 kbytes) Contains datablock I

	Structure factor file (CIF format) (179.0 kbytes) Contains datablock II

	Structure factor file (CIF format) (488.9 kbytes) Contains datablock III

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