Acta Crystallographica Section C

Crystal Structure Communications

Volume 60, Part 9 (September 2004)

dn1056 scheme

Acta Cryst. (2004). C60, o623-o626 [doi:10.1107/S0108270104014660]

Three 5H-indeno[1,2-c]pyridazin-5-one derivatives, potent type-B monoamine oxidase inhibitors

R. Frédérick, B. Norberg, F. Durant, F. Ooms and J. Wouters

Abstract: The structures of three compounds, namely 7-methoxy-2-[3-(trifluoromethyl)phenyl]-9H-indeno[1,2-c]pyridazin-9-one, C₁₉H₁₁F₃N₂O₂, (Id), 6-methoxy-2-[3-(trifluoromethyl)phenyl]-9H-indeno[1,2-c]pyridazin-9-one, C₁₉H₁₁F₃N₂O₂, (IId), and 2-methyl-6-(4,4,4-trifluorobutoxy)-9H-indeno[1,2-c]pyridazin-9-one, C₁₆H₁₃F₃N₂O₂, (IIf), which are potent reversible type-B monoamine oxidase (MAO-B) inhibitors, are presented and discussed. Compounds (Id) and (IId) crystallize in a nearly planar conformation. The crystal structures are stabilized by weak C-HO hydrogen bonds. The packing is dominated by [bold pi] - stacking interactions between the heterocyclic central moieties of centrosymmetrically related molecules. In compound (IIf), the trifluoroethyl termination is almost perpendicular to the plane of the ring.

Formula: C₁₉H₁₁F₃N₂O₂, C₁₉H₁₁F₃N₂O₂ and C₁₆H₁₃F₃N₂O₂

Online 11 August 2004


	Structure factor file (CIF format) (160.5 kbytes) Contains datablock Id

	Structure factor file (CIF format) (303.1 kbytes) Contains datablock IId

	Structure factor file (CIF format) (138.3 kbytes) Contains datablock IIf

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