Acta Crystallographica Section C

Crystal Structure Communications

Volume 62, Part 5 (May 2006)

organic compounds

tr3003 scheme

Acta Cryst. (2006). C62, o249-o252 [ doi:10.1107/S0108270106007992 ]

Di- and tripeptide segments of zervamicin II-2: Z-Thr(OBn)-Aib-N(Me)Ph and Z-Val-Aib-Hyp(OBn)-OMe

A. Linden, N. Pradeille and H. Heimgartner

Abstract: The title compounds, O-benzyl-N-(benzyloxycarbonyl)threonyl-2,N-dimethylalaninanilide, C₃₀H₃₅N₃O₅, and methyl (4R)-4-benzyloxy-N-(benzyloxycarbonyl)valyl-2-(methylalanyl)prolinate, C₃₀H₃₉N₃O₇, were obtained from the `azirine coupling' of the corresponding protected amino acids with 2,2,N-trimethyl-2H-azirin-3-amine and methyl (4R)-4-(benzyloxy)-N-(2,2-dimethyl-2H-azirin-2-yl)prolinate, respectively. The Aib unit in each molecule has the greatest turn- or helix-inducing effect on the molecular conformation. Intermolecular N-HO interactions link the molecules of the tripeptide into sheets and those of the dipeptide into extended chains.

Formula: C₃₀H₃₅N₃O₅ and C₃₀H₃₉N₃O₇


	Structure factor file (CIF format) (135.6 kbytes) [ doi:10.1107/S0108270106007992/tr3003IIIsup2.hkl ] Contains datablock III

	Structure factor file (CIF format) (164.6 kbytes) [ doi:10.1107/S0108270106007992/tr3003VIsup3.hkl ] Contains datablock VI

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