Acta Crystallographica Section C

Crystal Structure Communications

Volume 62, Part 9 (September 2006)

organic compounds

gz3025 scheme

Acta Cryst. (2006). C62, o577-o580 [ doi:10.1107/S0108270106028101 ]

Boc-Pro-Hyp-Gly-OBzl and Boc-Ala-Hyp-Gly-OBzl, two repeating triplets found in collagen

M. Doi, K. Imori, N. Sakaguchi and A. Asano

Abstract: The protected tripeptides benzyl N-{2-[N-(tert-butoxycarbonyl)prolyl]-4-hydroxyprolyl}glycinate or Boc-Pro-Hyp-Gly-OBzl, C₂₄H₃₃N₃O₇, and benzyl N-{2-[N-(tert-butoxycarbonyl)alanyl]-4-hydroxyprolyl}glycinate or Boc-Ala-Hyp-Gly-OBzl, C₂₂H₃₁N₃O₇, are the minimum repeating triplets found in collagen. Within the crystal structure of each are two independent peptide molecules with similar structures. The peptides are arranged antiparallel to one another and interact through hydrogen bonds involving the main chains and the 4-hydroxyprolyl groups. The structures exhibit characteristics of a triple helix, but the peptides tend to assume a sheet-like structure.

Formula: C₂₄H₃₃N₃O₇ and C₂₂H₃₁N₃O₇


	Structure factor file (CIF format) (283.5 kbytes) [ doi:10.1107/S0108270106028101/gz3025Isup2.hkl ] Contains datablock I

	Structure factor file (CIF format) (251.8 kbytes) [ doi:10.1107/S0108270106028101/gz3025IIsup3.hkl ] Contains datablock II

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