Acta Crystallographica Section C

Crystal Structure Communications

Volume 63, Part 12 (December 2007)


organic compounds



av3114 scheme

Acta Cryst. (2007). C63, o731-o733    [ doi:10.1107/S0108270107053218 ]

Monohydrous dihydrogen phosphate salts of norfloxacin and ciprofloxacin

B. Lou, D. Boström and S. P. Velaga

Abstract: Norfloxacin and ciprofloxacin crystallize with phosphoric acid in aqueous solution to give the salts 4-(3-carboxy-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-7-quinolyl)piperazinium dihydrogenphosphate monohydrate, C16H19FN3O3+·H2PO4-·H2O, and 4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-7-quinolyl)piperazinium dihydrogenphosphate monohydrate, C17H19FN3O3+·H2PO4-·H2O, respectively. In the crystal structures, the phosphate anions and the piperazine rings of norfloxacin or ciprofloxacin form a 12-membered supramolecular synthon, viz. R44(12). The synthons R44(12) and R22(8) formed between adjacent phosphate anions result in the three-dimensional structures.

Formula: C16H19FN3O3+·H2PO4-·H2O and C17H19FN3O3+·H2PO4-·H2O


hkldisplay filedownload file

Structure factor file (CIF format) (265.6 kbytes)
[ doi:10.1107/S0108270107053218/av3114Isup2.hkl ]
Contains datablock I


hkldisplay filedownload file

Structure factor file (CIF format) (272.6 kbytes)
[ doi:10.1107/S0108270107053218/av3114IIsup3.hkl ]
Contains datablock II


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