Acta Cryst. (2007). C63, o731-o733 [ doi:10.1107/S0108270107053218 ]
Abstract: Norfloxacin and ciprofloxacin crystallize with phosphoric acid in aqueous solution to give the salts 4-(3-carboxy-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-7-quinolyl)piperazinium dihydrogenphosphate monohydrate, C16H19FN3O3+·H2PO4-·H2O, and 4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-7-quinolyl)piperazinium dihydrogenphosphate monohydrate, C17H19FN3O3+·H2PO4-·H2O, respectively. In the crystal structures, the phosphate anions and the piperazine rings of norfloxacin or ciprofloxacin form a 12-membered supramolecular synthon, viz. R44(12). The synthons R44(12) and R22(8) formed between adjacent phosphate anions result in the three-dimensional structures.
Formula: C16H19FN3O3+·H2PO4-·H2O and C17H19FN3O3+·H2PO4-·H2O
Structure factor file (CIF format) (265.6 kbytes)
Structure factor file (CIF format) (272.6 kbytes)
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