Acta Crystallographica Section C

Crystal Structure Communications

Volume 64, Part 8 (August 2008)


organic compounds



fa3148 scheme

Acta Cryst. (2008). C64, o441-o444    [ doi:10.1107/S0108270108020374 ]

Nitrated isomers of 2-(trichloromethyl)quinoline

J. Sopková-de Oliveira Santos, P. Verhaeghe, J.-F. Lohier, P. Rathelot, P. Vanelle and S. Rault

Abstract: In the closely related quinoline compounds 8-nitro-2-(trichloromethyl)quinoline, (I), 6-nitro-2-(trichloromethyl)quinoline, (II), and 5-nitro-2-(trichloromethyl)quinoline, (III), all C10H5Cl3N2O2, which are of both reactivity and pharmacological interest, and for which the biological activity and cytotoxicity appear to be based on the positions of the CCl3 and nitro substituents, the nitro group is only coplanar with its aromatic substrate in (II). The deviation of the nitro group from coplanarity is concluded to be a function of both its position with respect to the trichloromethyl group and the intermolecular contacts in which it participates. The discrepancies between the crystal structures and the molecular shapes predicted by ab initio calculations are also explained in these terms. The quinoline ring is not rigorously planar in any of the structures, which may be explained by stress produced by the CCl3 substituent.

Formula: Three isomers of C10H5Cl3N2O2


hkldisplay filedownload file

Structure factor file (CIF format) (316.3 kbytes)
[ doi:10.1107/S0108270108020374/fa3148Isup2.hkl ]
Contains datablock I


hkldisplay filedownload file

Structure factor file (CIF format) (652.3 kbytes)
[ doi:10.1107/S0108270108020374/fa3148IIsup3.hkl ]
Contains datablock II


hkldisplay filedownload file

Structure factor file (CIF format) (288.8 kbytes)
[ doi:10.1107/S0108270108020374/fa3148IIIsup4.hkl ]
Contains datablock III


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