Acta Crystallographica Section C

Crystal Structure Communications

Volume 64, Part 10 (October 2008)

organic compounds

gg3168 scheme

Acta Cryst. (2008). C64, o547-o549 [ doi:10.1107/S0108270108029326 ]

Novel chalcones derived from 2-chloro-3-formyl-6-methylquinoline

U. F. Rizvi, H. L. Siddiqui, S. Ahmad, M. Ahmad and M. Parvez

Abstract: Molecules of (E)-3-(2-chloro-6-methylquinolin-3-yl)-1-(5-iodo-2-thienyl)prop-2-en-1-one, C₁₇H₁₁ClINOS, (I), and (E)-3-(2-chloro-6-methylquinolin-3-yl)-1-(5-methyl-2-furyl)prop-2-en-1-one, C₁₈H₁₄ClNO₂, (II), adopt conformations slightly twisted from coplanarity. Both structures are devoid of classical hydrogen bonds. However, nonclassical C-HO/N interactions [with CO = 3.146 (5) Å and CN = 3.487 (3) Å] link the molecules into chains extended along the b axis in (I) and form dimers with an R₂²(8) motif in (II). The structural analysis of these compounds provides an insight into the correlation between molecular structures and intermolecular interactions in compounds for drug development.

Formula: C₁₇H₁₁ClINOS and C₁₈H₁₄ClNO₂


	Structure factor file (CIF format) (175.4 kbytes) [ doi:10.1107/S0108270108029326/gg3168Isup2.hkl ] Contains datablock I

	Structure factor file (CIF format) (161.3 kbytes) [ doi:10.1107/S0108270108029326/gg3168IIsup3.hkl ] Contains datablock II

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