Acta Cryst. (2009). C65, o574-o578 [ doi:10.1107/S010827010903950X ]
Abstract: In order to better understand the interaction between the pharmaceutically active compound 5-fluorocytosine [4-amino-5-fluoropyrimidin-2(1H)-one] and its receptor, hydrogen-bonded complexes with structurally similar bonding patterns have been investigated. During the cocrystallization screening, three new pseudopolymorphs of 5-fluorocytosine were obtained, namely 5-fluorocytosine dimethyl sulfoxide solvate, C4H4FN3O·C2H6OS, (I)
N and N-HO hydrogen bonds. The solvent molecules adopt similar positions with respect to 5-fluorocytosine. Depending on the hydrogen bonds formed by the solvent, the 5-fluorocytosine ribbons form layers or tubes. A database study was carried out to compare the hydrogen-bond pattern of compounds (I)
Formula: C4H4FN3O·C2H6OS, C4H4FN3O·0.5C4H9NO and C4H4FN3O·0.5H2O
 |   Structure factor file (CIF format) (93.7 kbytes) |
| Structure factor file (CIF format) (142.9 kbytes) |
| Structure factor file (CIF format) (105.3 kbytes) |
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