Acta Cryst. (2014). C70, 392-395 [ doi:10.1107/S2053229614003684 ]
Abstract: A new polymorph of the cinnamic acid-isoniazid cocrystal has been prepared by slow evaporation, namely cinnamic acid-pyridine-4-carbohydrazide (1/1), C9H8O2·C6H7N3O. The crystal structure is characterized by a hydrogen-bonded tetrameric arrangement of two molecules of isoniazid and two of cinnamic acid. Possible modification of the hydrogen bonding was investigated by changing the hydrazide group of isoniazid via an in situ reaction with acetone and cocrystallization with cinnamic acid. In the structure of cinnamic acid-N'-(propan-2-ylidene)isonicotinohydrazide (1/1), C9H8O2·C9H11N3O, carboxylic acid-pyridine O-HN and hydrazide-hydrazide N-HO hydrogen bonds are formed.
CCDC references: 987640 and 987641
Formula: C6H7N3O·C9H8O2 and C9H11N3O·C9H8O2
Keywords: crystal structure; cinnamic acid-isoniazid cocrystal; hydrogen bonding; modification of hydrogen bonding; pharmaceutically active compound; in situ modification.
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