November 1993 issue
Cover illustration: Stereoview of a fragment of DNA form B. Courtesy of A. Soyer.
A carbonmonoxyhaemoglobin from river buffalo (Bubalus bubalis) BB phenotype has been crystallized. Crystals diffract to a resolution of 2.8 Å.
Energy-minimization studies reveal a large conformational change that closes the substrate-access cleft thereby providing enhanced protein-substrate interactions.