Figure 7 Stereoview of the superposition of PfPNP-ino (light green), PfPNP-SO4 (only the sulfate is shown, in blue) and PfPNP-immucillin (yellow). The loop above the binding pocket of the immucillin-H complex structure is complete and shows a water-mediated bond between residues Asp218 and Asp206, whereas in the other two structures the loop is disordered or flexible and the model cannot be built. The PfPNP-immucillin structure shows a water-mediated interaction of Asp206 and Trp212 with the inhibitor. In PfPNP-ino, the substrate does not form these bonds and is shifted relative to immucillin-H, together with the aromatic residues Trp212 and Tyr160.

© International Union of Crystallography 2005