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![[Figure 3]](en5210fig3mag.jpg)
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Figure 3
(a) Stereoview of the TgENR monomer in complex with NAD+ and triclosan, coloured from blue (N-terminus) to red (C-terminus), with each secondary-structure element labelled. The atom colours for triclosan and the NAD+ cofactor are yellow, blue, red, purple and green for carbon, nitrogen, oxygen, phosphorus and chlorine, respectively. (b) Surface representation of the TgENR monomer, showing the distribution of electrostatic charge. The position of the inserted loop, which is a feature of the apicomplexan family, is displayed below the partially transparent depiction of the protein surface as a stick representation and Lys237, which is fully conserved within the loop region of the apicomplexan family, is labelled. The position of the NAD+ cofactor and the triclosan inhibitor which define the active site and the ACP-binding region are shown, demonstrating their proximity to Lys237. |
![[Figure 3]](en5210fig3.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
