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Cover illustration: Active site of exonuclease I at 1.5 Å resolution with a TMP molecule bound. Omit electron density is contoured at 3 . Also observed is atypical coordination of two critical divalent cations which may be relevant to the mechanism of hydrolysis (p. 206). |
Acta Cryst. (2008). D64, 141-148 [ doi:10.1107/S090744490705559X ] Surface-entropy reduction approaches to manipulate crystal forms of
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Acta Cryst. (2008). D64, 149-157 [ doi:10.1107/S0907444907057228 ] Structures of potent selective peptide mimetics bound to carboxypeptidase BM. Adler, B. Buckman, J. Bryant, Z. Chang, K. Chu, K. Emayan, P. Hrvatin, I. Islam, J. Morser, D. Sukovich, C. West, S. Yuan and M. WhitlowSynopsis: A series of structures show the development of novel inhibitors of carboxypeptidase B. These inhibitors were designed to mimic peptide-based inhibitors of the protein. PDB references: 2piy, 2piz, 2pj0, 2pj1, 2pj2, 2pj3, 2pj4, 2pj5, 2pj6, 2pj7, 2pj8, 2pj9, 2pja, 2pjb and 2pjc Online 16 January 2008 |
Acta Cryst. (2008). D64, 158-166 [ doi:10.1107/S090744490705812X ] Protein crystallography with a micrometre-sized synchrotron-radiation beamR. Moukhametzianov, M. Burghammer, P. C. Edwards, S. Petitdemange, D. Popov, M. Fransen, G. McMullan, G. F. X. Schertler and C. RiekelSynopsis: For the first time, protein microcrystallography has been performed with a focused synchrotron-radiation beam of 1 µm using a goniometer with a sub-micrometre sphere of confusion. The crystal structure of xylanase II has been determined with a flux density of about 3 × 1010 photons s-1 µm-2 at the sample. PDB reference: 2jic Online 16 January 2008 |
Acta Cryst. (2008). D64, 167-171 [ doi:10.1107/S0907444907058416 ] A novel method for detection of selenomethionine incorporation in protein crystals via Raman microscopyA. Vergara, A. Merlino, E. Pizzo, G. D'Alessio and L. MazzarellaSynopsis: A novel methodological development for the analysis, via Raman microscopy, of SeMet-labelled protein crystals is presented. Online 16 January 2008 |
Acta Cryst. (2008). D64, 172-177 [ doi:10.1107/S0907444907058659 ] Rapid and automated substructure solution by Shake-and-BakeH. Xu and C. M. WeeksSynopsis: The computer program SnB, which implements the direct-methods Shake-and-Bake procedure and is part of the protein structure-determination package BnP, has recently been optimized in several ways for more rapid, automated substructure determination. Online 16 January 2008 |
Acta Cryst. (2008). D64, 178-188 [ doi:10.1107/S0907444907059021 ] Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIMM. Alahuhta, M. G. Casteleijn, P. Neubauer and R. K. WierengaSynopsis: Crystal structures of unliganded and liganded complexes of the A178L variant of dimeric and monomeric trypanosomal TIM are reported. The A178L point mutation changes the conserved sequence pattern of the C-terminal hinge of the catalytic loop-6. The point mutation causes differences in the apo structures but not in the liganded structures. PDB references: 2v0t, 2v2c, 2v2d and 2v2h Online 16 January 2008 |
Acta Cryst. (2008). D64, 189-197 [ doi:10.1107/S0907444907060064 ] In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannelsJ. D. Ng, P. J. Clark, R. C. Stevens and P. KuhnSynopsis: Plastic microchannel crystallization template designs made from inexpensive cyclic olefin copolymers have been shown to be low-birefringent, X-ray transmissive and compatible with microfluidic fabrication in restricted geometry. The model proteins thaumatin, lysozyme and bacteriorhodopsin demonstrated the feasibility of conducting counter-diffusion equilibration within the new plastic configuration. Online 16 January 2008 |
Acta Cryst. (2008). D64, 198-205 [ doi:10.1107/S0907444907059835 ] Structural and functional analysis of the TetR-family transcriptional regulator SCO0332 from Streptomyces coelicolorU. Okada, K. Kondo, T. Hayashi, N. Watanabe, M. Yao, T. Tamura and I. TanakaSynopsis: The crystal structure of SCO0332 was determined; functional analysis suggests that SCO0332 is a transcriptional repressor of the sco0330 gene. PDB reference: 2zb9 Online 16 January 2008 |
Acta Cryst. (2008). D64, 206-210 [ doi:10.1107/S090744490706012X ] Structure of Escherichia coli exonuclease I in complex with thymidine 5'-monophosphateR. D. BusamSynopsis: The structure of Escherichia coli exonuclease I in complex with a nucleotide product, thymidine 5'-monophosphate, is described in an orthorhombic space group at 1.5 Å resolution. PDB reference: 2qxf Online 16 January 2008 |
Acta Cryst. (2008). D64, 211-218 [ doi:10.1107/S0907444907065390 ] High-resolution structure of methionine
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Acta Cryst. (2008). D64, 219-220 [ doi:10.1107/S0907444907056132 ] Alternative models for two crystal structures of Candida albicans 3,4-dihydroxy-2-butanone 4-phosphate synthaseI. Le Trong and R. E. StenkampSynopsis: The noncrystallographic symmetry operations reported for two crystal structures of 3,4-dihydroxy-2-butanone 4-phosphate synthase can be reinterpreted as crystallographic operations. Online 16 January 2008 |
Acta Cryst. (2008). D64, 221-226 [ doi:10.1107/S0907444907053231 ] Notes for authors 2008Online 16 January 2008 |
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