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Cover illustration: GlmU is the bifunctional acetyltransferase/uridyltransferase that catalyses the conversion of GlcN-1-P to UDP-GlcNAc, a key substrate in lipopolysaccharide and peptidoglycan synthesis. The cover figure shows the biological trimer of the M. tuberculosis enzyme, an important drug target, complexed with the product UDP-GlcNAc (top: uridyltransferase active site) and with cacodylate anion (middle: on the crystallographic threefold axis). The acetyl-coA cofactor has been modelled in the acetyltransferase active site (bottom) (p. 275). |
Acta Cryst. (2009). D65, 201-211 [ doi:10.1107/S0907444908041115 ]
Synopsis: The structures of the two alternatively spliced isoforms of human ketohexokinase, hepatic KHK-C and peripheral KHK-A, and of the ternary complex of KHK-A with the substrate fructose and AMP-PNP have been solved. The differences between KHK-A and KHK-C resulting from the spliced region are subtle and affect thermostability and probably flexibility; the mutations causing fructosuria were modelled.
PDB references: 2hqq, 2hw1 and 3b3l
Online 20 February 2009
Acta Cryst. (2009). D65, 212-219 [ doi:10.1107/S0907444908041474 ]
Synopsis: The structure of the DUF55 domain of human thymocyte nuclear protein 1, which was determined from partially tetartohedrally twinned crystals, is reported.
PDB reference: 3eop
Online 20 February 2009
Acta Cryst. (2009). D65, 220-228 [ doi:10.1107/S0907444908041814 ]
Synopsis: The structure of the lysosomal 66.3 kDa protein, which crystallizes in the monoclinic space group C2, was solved by means of sulfur SAD phasing using data with an Ranom/Rp.i.m. ratio of 1.1.
PDB reference: 3fbx
Online 20 February 2009
Acta Cryst. (2009). D65, 229-240 [ doi:10.1107/S0907444908043023 ]
Synopsis: The structure of SoxS has been solved in oxidized and reduced forms at 2.1 and 1.9 Å resolution, respectively.
Online 20 February 2009
Acta Cryst. (2009). D65, 241-248 [ doi:10.1107/S0907444908043679 ]
Synopsis: The crystal structures of DAPK-ADP-Mg2+ and DAPK-AMP-PNP-Mg2+ complexes were determined at 1.85 and 2.00 Å resolution, respectively. Comparison of the two nucleotide-bound states with apo DAPK revealed localized changes in the glycine-rich loop region that were indicative of a transition from a more open state to a more closed state on binding of the nucleotide substrate and to an intermediate state with the bound nucleotide product.
PDB references: 3f5g, 3f5u, 3eh9 and 3eha
Online 20 February 2009
Acta Cryst. (2009). D65, 249-256 [ doi:10.1107/S0907444908043734 ]
Synopsis: A revised EDM-DEDM algorithm for phase refinement is described, together with its application to proteins, with special attention being given to molecular-replacement cases.
Online 20 February 2009
Acta Cryst. (2009). D65, 257-265 [ doi:10.1107/S0907444908044028 ]
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-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrateSynopsis: Structure of the G225P/G226P mutant of mouse 3(17)-hydroxysteroid dehydrogenase (AKR1C21) ternary complex is reported at 2.1 Å resolution.
PDB reference: 3cv6
Online 20 February 2009
Acta Cryst. (2009). D65, 266-274 [ doi:10.1107/S0907444909000389 ]
Synopsis: The crystal structure of C2b has been determined at 1.8 Å resolution, which reveals the arrangement of its three complement control protein (CCP) modules. A model for complement component C2 is presented and its conformational changes during the C3-convertase formation are also discussed.
PDB reference: 3erb
Online 20 February 2009
Acta Cryst. (2009). D65, 275-283 [ doi:10.1107/S0907444909001036 ]
Synopsis: The crystal structure of M. tuberculosis GlmU has been determined in an unliganded form and in complex with UDP-GlcNAc or GlcN-1-P. NMR-based enzymatic activity assays suggest that the presence of acetyl-coenzyme A has an inhibitory effect on uridyltransferase activity.
PDB references: 2qkx, 3d8v and 3d98
Online 20 February 2009
Acta Cryst. (2009). D65, 284-293 [ doi:10.1107/S0907444908040602 ]
Synopsis: Two single-crystal X-ray diffraction data sets for cyclosporine A were measured to high resolution using synchrotron radiation at temperatures of 5 and 90 K. They allowed an accurate determination of its molecular and electronic structure.
Online 20 February 2009
Acta Cryst. (2009). D65, 294-296 [ doi:10.1107/S0907444908041632 ]
Synopsis: The structure of uncomplexed plasmepsin II from P. falciparum is shown to contain noncoplanar catalytic aspartic acid residues.
PDB reference: 3f9q
Online 20 February 2009
Acta Cryst. (2009). D65, 297-300 [ doi:10.1107/S0907444908044296 ]
Synopsis: The representation of crystallographic model characteristics in the form of a polygon allows the quick comparison of a model with a set of previously solved structures.
Online 20 February 2009
Acta Cryst. (2009). D65, 301 [ doi:10.1107/S0907444909005824 ]
Synopsis: A corrigendum to the article by Kato et al. [Acta Cryst. (2008). D64, 525-531].
Online 20 February 2009
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