Figure 3
Superimposition of six crystal structures of BACE1. Only the bound ligand and the three loops including residues 5-16, 67-77 and 105-117 are shown. (a) The BSIIV complex obtained by cocrystallization (green), the BSIIV complex obtained by soaking (cyan) and the previously deposited BSIIV-BACE1 structure, also obtained by soaking (PDB entry 2b8l ; yellow). (b) Apo enzymes: Apo1 structure (magenta), Apo2 structure (purple) and the previously deposited apo structure of BACE1 (PDB entry 1w50 ; light pink). (c) Superimposition of the six structures shown in (a) and (b).  [article HTML]

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