Supporting Information: 

PDB IDs Used

2NNU
3KA5
2QM0
3ESM
1VAJ
3MWB
3KMI
3KXW
3K3V
1OI0
3ZY0
3MX7
3G5J
1LZL
3PKZ
3PSH
1M4I
1GUT
1GP0
3BDU
3G23
1XAK
3MTQ
2W9R
2QR6
2TGI
3F0I
3CVJ
3GK7
2WLC
2Z62
2AXC
1LM8
3C22
3HN0
2O90
3L00
2HDO
2EPL
2E26
3MGK
3DQG
3DML
1YG9
3FEU
2BEZ
2GWM
3NYC
1NAR
2V5M
2X0K
3BO6
3L3B
3B35
3PG6
3MR0
3AON
3RVC
2CHH
2C2U
3HIE
3D79
3BZN
2IJQ
1W94
1JVW
3P8K
2IY9
3NGG
3H8G
2XVM
2INU
1WS8
3BON
2GUX
2BL9
3DJ9
1ALU
3Q60
1QFO
3FVA
1OMR
3KBY
1ZKP
2IIH
1Z2U
1W6U
2BK8
2VLI
2C1I
2PQV
3AHN
1F46
3PIC
1M15
1M1S
2FVV
2DPQ
3DRZ
3D0F
1BGV
1RXQ
2X7B
3MWZ
3MAD
1LFP
3HGU
3RY4
1TJV
2ZSG
2YG5
1GV9
1IJB
1K12
3ATS
2HY1
2QM8
2WW5
1DUV
3S9D
1LQT
2VVE
1W2I
3BG2
2JKB
1R3D
3G9T
3FF5
3KFH
2HAL
3FWK
2EZ9
1NU4
3NVE
3HNY
3FG8
2D39
2YA0
1CDC
3L8Q
3ITQ
3FOT
1YD0
2BJQ
3FJV
2OCG
1YN9
2PDO
1M1R
1GWY
1NQZ
2QM6
2QLX
1OC7
3QYF
1YPH
1ITU
2ERW
2W39
2BC3
2R60
2B82
1Z96
2I71
2QIF
1GXM
2GZQ
2V6V
1GS9
2GR8
1I7N
3L41
2F60
3KHE
1L8R
2UUU
3T8W
3KT9
2WWF
1J24
2OSX
1OQC
2OD0
3LOU
3QY7
1PDO
2DHO
3DLM
1SFP
1VH4
3GRH
1ZUK
3FR1
3NI0
3VGZ
1C0Q
1H9M
3NEC
1FIP
1PXZ
2IW0
2G5D
1PBY
1XMT
2OKZ
1NP8
2Z98
3C6K
1ODV
3AA0
2BDR
3HJH
1NJK
1F39
1L9X
2WKX
1TZJ
2JJQ
1YJP
1EU1
3IAN
3ISR
1JF8
1MSO
1W8O
1SYY
3BBB
3D1B
2W3Y
3HKM
3AJ7
1QWR
2WF7
3C85
1HUF
3RAG
2VFK
3LET
2I7A
3K3C
3III
1RH9
3EJG
2NZL
3ARX
1H75
3JS6
3TRG
1RSG
1ZL0