1It is known that AH is matured by reducing the N-terminal extension gradually during cultivation of the microorganism (Suzuki et al., 2012BB38).

2The peptide folding is classified as CBM family 13 (Hazes, 1996BB19; Gilkes et al., 1991BB18), which contains many proteins that differ in function but are similar to each other in tertiary structure with a stable scaffold.