Figure 5
The interactions of the trisaccharide ligand (orange) bound at the -1, -2 and -3 subsites of the protein. The key protein residues are shown in yellow and hydrogen bonds are marked by dashes. Note the site of the Ala259 mutation: the space freed by the side chain of Glu259 was occupied by the sugar unit -1, which is now in a relaxed 4C1 conformation.  [article HTML]

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