Figure 16
Absent inhibitor: the peptide inhibitor in the structure of phospholipase A2 (PDB entry 1jq8 ; Chandra et al., 2002BB12). The electron-density maps downloaded from the EDS show that the placed ligand overlaps with negative difference density below the -3[sigma] level (a), while the omit maps do not support the presence of the ligand in the active site of the enzyme (b). (b) shows the 2.0 Å resolution mFo - DFc map contoured at ±3[sigma] (green/red) and 2mFo - DFc maximum-likelihood omit map contoured at 1[sigma] (blue). Maps were calculated for a refined model with the ligand atoms omitted.  [article HTML]

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