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![[Figure 4]](wd5191fig4mag.jpg)
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Figure 4
Missing density: detergents. Two examples of detergent molecules placed into models of membrane proteins. (a) The plant SLAC1 anion channel structure, PDB entry 3m73 (Chen et al., 2010  ), shows two molecules (BOG A317/A318) that have clear density for the hydrophobic acyl chain but not for the head groups. (b) The presence of detergent molecules (BOG A700/A801 is shown) in the crystal structure of the Escherichia coli membrane enzyme glycerol-3-phosphate dehydrogenase, PDB entry 2qcu (Yeh et al., 2008), appears to be entirely unsupported by the electron density. The 1.15 Å (a) and 1.75 Å (b) resolution mFo − DFc maps contoured at ±3σ (green/red) and 2mFo − DFc maximum-likelihood omit maps contoured at 1σ (blue) are shown. Maps were calculated for a refined model with the ligand atoms omitted. |
![[Figure 4]](wd5191fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
