Overall structure of LdtMt2Δ130. (a) Ribbon diagram of meropenem-complexed LdtMt2Δ130. The NTD and the Ldt domain are shown in green and yellow, respectively. The active-site lid (His300–Asp323) and the C-terminal tail (Asn379–Ala408) are coloured red and blue, respectively. Meropenem bound to the Ldt domain is shown as a stick model. (b) Domains of Mtb LdtMt2 coloured as in (a). TM, transmembrane helix. (c) Topology diagram of LdtMt2Δ130 coloured as in (a). (d) Electrostatic surface diagram of meropenem-complexed LdtMt2Δ130. Blue and red indicate positive and negative electrostatic potentials at neutral pH, respectively.