Figure 1
Overall structure of LdtMt2[Delta]130. (a) Ribbon diagram of meropenem-complexed LdtMt2[Delta]130. The NTD and the Ldt domain are shown in green and yellow, respectively. The active-site lid (His300-Asp323) and the C-terminal tail (Asn379-Ala408) are coloured red and blue, respectively. Meropenem bound to the Ldt domain is shown as a stick model. (b) Domains of Mtb LdtMt2 coloured as in (a). TM, transmembrane helix. (c) Topology diagram of LdtMt2[Delta]130 coloured as in (a). (d) Electrostatic surface diagram of meropenem-complexed LdtMt2[Delta]130. Blue and red indicate positive and negative electrostatic potentials at neutral pH, respectively.  [article HTML]