Acta Crystallographica Section D

Biological Crystallography

Volume 69, Part 8 (August 2013)

research papers

Acta Cryst. (2013). D69, 1580-1586    [ doi:10.1107/S0907444913010949 ]

Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata

M. Shankar, S. M. Wilbanks, Y. Nakatani, B. C. Monk and J. D. A. Tyndall

Abstract: Candida glabrata has emerged as an important fungal pathogen with intrinsic resistance to azole drugs. The limited efficacy of and resistance to existing antifungals is driving the need to identify new drug targets. The enzyme 6,7-dimethyl-8-­(D-ribityl)lumazine synthase is part of the riboflavin-biosynthesis pathway essential to fungi and bacteria and is a potential drug target for the development of broad-spectrum antifungal drugs. The X-ray crystal structure of recombinant lumazine synthase from C. glabrata was obtained at 2.24 Å resolution and revealed a dimer of homopentamers, with one in five subunits containing a product molecule from the catalytic reaction.

PDB reference: 4kq6

Keywords: Candida glabrata; lumazine synthase; 6,7-dimethyl-8-(D-ribityl)lumazine; fungal pathogens.

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