HSV-2 gD–E317-Fab interaction interface. (a) The epitope on HSV-2 gD is shown as an electrostatic surface that contains protrusions and concave cavities for water molecules and amino acids packed with the CDRs of E317-Fab. The heavy-chain and light-chain CDRs are shown as ribbons and the contacting residues are shown as stick models with green and orange C atoms. The water molecule is shown here as a magenta sphere. (b) The corresponding interactions are depicted using stick models. gD is shown as a yellow ribbon and sticks with yellow C atoms. All residues involved in direct contact between gD and E317-Fab are indicated and shown as sticks. Hydrogen bonds are shown as dashed lines. A water molecule (magenta) is also indicated.