Figure 2
Structural comparison of nucleosomes containing H2A.Z.1, H2A.Z.2 and H2A. (a) Superimposition of the H2A.Z.1 nucleosome on the canonical H2A nucleosome (PDB entry 3afa ; Tachiwana et al., 2010BB45). The r.m.s.d. values were calculated and plotted for each C[alpha]-atom pair of H2A.Z.1 and H2A. Residue numbers correspond to H2A. The r.m.s.d. value for position 98 is missing because the corresponding residue is absent in H2A.Z.1. The secondary structure of H2A in the nucleosome is shown at the top of the panel. (b) A close-up view around the L1 loop regions of H2A.Z.1 (blue) and H2A (grey) in the nucleosomes. The H2A.Z.1 Ser38 and H2A Lys36 residues, which are located just before the L1 loop, are represented with their side chains. (c) Superimposition of the H2A.Z.2 nucleosome on the canonical H2A nucleosome. The r.m.s.d. values were calculated and plotted for each C[alpha]-atom pair of H2A.Z.2 and H2A. Residue numbers correspond to H2A. The r.m.s.d. value for position 98 is missing because the corresponding residue is absent in H2A.Z.2. The secondary structure of H2A in the nucleosome is shown at the top of the panel. (d) A close-up view around the L1 loop regions of H2A.Z.2 (magenta) and H2A (grey) in the nucleosomes. The H2A.Z.2 Thr38 and H2A Lys36 residues, which are located just before the L1 loop, are represented with their side chains. (e) Superimposition of the H2A.Z.1 nucleosome on the H2A.Z.2 nucleosome. The r.m.s.d. values were calculated and plotted for each C[alpha]-atom pair of H2A.Z.1 and H2A.Z.2. Residue numbers correspond to H2A.Z.1 or H2A.Z.2. The secondary structure of H2A.Z.1 or H2A.Z.2 in the nucleosome is shown at the top of the panel. (f) A close-up view around the L1 loop regions of H2A.Z.1 (blue) and H2A.Z.2 (magenta) in the nucleosomes. The H2A.Z.1 Ser38 and H2A.Z.2 Thr38 residues, which are located just before the L1 loop, are represented with their side chains.  [article HTML]