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Figure 3
Overall structure of the astacin catalytic domain and NleC in comparable orientations. (a) Cartoon representation of astacin depicting its secondary structure in the N-lobe subdomain together with the Met-turn and the 170-loop. (b) Cartoon representation of NleC; the secondary structures corresponding to those in astacin are labelled. The conserved residue Arg232 is shown in stick representation. (c) Activity of mutants of p65 around the scissile bond. (d) Sequence alignment between p65 and p50 around the cleavage site.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
Volume 70| Part 1| December 2014| Pages 40-47
doi:10.1107/S1399004713024619
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