journal menu
![[Figure 3]](kw5073fig3mag.jpg)
|
|
Figure 3
Two examples of rare isoleucine rotamers that were unambiguously observed in good electron density in structures determined at around 1.0 Å resolution. Left: Ile337 in chain A of the triacylglycerol lipase protein (PDB entry 1d5t; Brzozowski et al., 2000  ) is observed in section 1. Right: Ile15 in chain B of the HIV protease (PDB entry 1kzk; Reiling et al., 2002) is observed in section 2. Electron densities were obtained from the EDS server and are contoured at 1.4σ. At https://swift.cmbi.ru.nl/gv/isoleucine/ the local structures of these residues are shown and the interactions that keep the residues in these unfavourable rotamers are explained. MolProbity (Chen et al., 2010) and WHAT_CHECK (Hooft, Vriend et al., 1996) call these two rotamers `poor'. We believe that `improbable' is a better description. |
![[Figure 3]](kw5073fig3.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
Open 
access
access
