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Figure 5
Val550 is a buried internal residue in IL-17RA SEFIR. The missing fragment (residues 541–555) connecting helices αE and αE′ of the crystal structure was modeled using FALC-Loop (https://falc-loop.seoklab.org/). Residue Val550 is located on helix αM and is buried inside the protein, making extensive hydrophobic contacts with three aromatic residues from helices αA (Phe401), αE (Phe529) and αE′ (Tyr558). The V550H mutation will disrupt the structural integrity.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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