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![[Figure 2]](mn5051fig2mag.jpg)
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Figure 2
(a) Cartoon representation of the LDH-A apo-structure tetramer with crystallographically independent molecules depicted in purple and yellow, respectively. Active-site loops are circled and the location of the NADH-binding pocket is indicated by white spheres. NBP denotes the `nicotinamide moiety binding pocket' and ABP denotes the `adenine moiety binding pocket'. (b) Close-up view of the σA-weighted 2Fobs − Fcalc electron-density map of the active-site loop contoured at the 1.1σ level (grey) with residues labelled and side chains shown as sticks depicted in purple. |
![[Figure 2]](mn5051fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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