journal menu
![[Figure 4]](nj5173fig4mag.jpg)
|
|
Figure 4
Placing multiple experiments on a single specimen holder allows the goniometer to act as an `auxiliary robotic automounter' that rapidly translates between experiments during the time that the conventional cryogenic automounter completes its duty cycle. (a) shows in situ co-crystallization of thermolysin, precipitant, cryoprotectant and fragments. In this example the fragments were asparagine (bottom), histidine (middle) and a control with no ligand (top). The custom specimen holder has sufficient space to accommodate ten discrete experiments (b) (with no ligands or cryoprotectants). Even with such a high density of specimens, the spacing between droplets is adequate to prevent cross-contamination (inset). A video is available on our website showing multiple crystals growing in situ directly on custom MiTeGen paddles, each with a different fragment (URL in §2.2 ![[link]](../../../../../../logos/arrows/d_arr.gif) ). |
![[Figure 4]](nj5173fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
access
