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Figure 3
Detailed view of BurrH–DNA binding and the new BSR interactions. (a) Inter-repeat hydrophobic cluster built by four of the strictly conserved amino acids upon DNA binding. (b) General view of the protein–DNA association depicting the arrangement of the conserved polar stripes (composed of Lys/Arg and Gln at positions 8 and 17 of the BuD repeats, respectively) stabilizing the phosphate backbone of the noncoding and coding DNA strands. (c) Recognition of A+4 by Thr193 in the fourth BuD repeat. (d) Detailed view of the interaction of Arg490 with the duplex DNA establishing key interactions with both DNA stands. The electron-density map for all of the figures is a 2Fo − Fc σA-weighted map contoured at 1.2σ.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 70| Part 7| July 2014| Pages 2042-2052
https://doi.org/10.1107/S1399004714011183
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