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![[Figure 2]](dw5123fig2mag.jpg)
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Figure 2
Stereoviews showing detail of monovalent cation-binding site 1 in the models of E. coli GyrB43 presented here. (a) K-only model refined with a fully occupied K+ ion at 1.75 Å resolution; the equivalent site in the K+Na model is virtually identical (not shown). (b) Na-only model refined with a discretely disordered Na+ ion at 1.90 Å resolution. (c) No-salt model refined with a fully occupied water molecule at 1.95 Å resolution (all electron-density maps shown are of the form 2mFobs − DFcalc and are contoured at 1.0σ). (d) Equivalent site in yeast topoisomerase II (PDB entry 1pvg) showing how the Nζ atom of Lys147 effectively substitutes for the K+ ion seen in the GyrB43 K-only structure. |
![[Figure 2]](dw5123fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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