Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition

Lin, C.-C.; Chuankhayan, P.; Chang, W.-N.; Kao, T.-T.; Guan, H.-H.; Fun, H.-K.; Nakagawa, A.; Fu, T.-F.; Chen, C.-J.

doi:10.1107/S1399004715002928

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 6
Structural comparison of the zNt-FDH–10-FDDF/THF complex with the human Nt-FDH–6-formyltetrahydropterin and rat Nt-FDH–β-mercaptoethanol complexes. 10-FDDF (orange), THF (yellow), 6-formyltetrahydropterin (magenta) and β-mercaptoethanol (red) are shown in ball-and-stick representation. Residues in the zNt-FDH–THF (cyan), human Nt-FDH–6-formyltetrahydroptein (magenta) and rat Nt-FDH–β-mercaptoethanol (red) structures are shown in stick representation.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 71| Part 4| April 2015| Pages 1006-1021

https://doi.org/10.1107/S1399004715002928

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