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Figure 2
Bait-region interaction with the CTMG domain. (a) Here we show hydrogen bonding between the cleaved bait region (blue) and the CTMG domain (grey) as dashed yellow lines. Note the interaction between Arg956 and Met1634, with the CTMG methionine normally involved in the hydrophobic pocket found in uncleaved native SaA2M. MG4 and MG9 are shown in yellow and red, respectively. (b) Surface representation of the CTMG domain bound to the TED in SaA2M (blue) overlaid (by superposition of CTMG domains) with the previously disordered bait region bound to the CTMG domain in elastase-cleaved ECAM (red). The thioester bond within the TED is shown as dark blue van der Waals spheres.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
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