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Figure 5
The electrostatic surface of the human recombinant ALAD octamer. (a) A cutaway view looking along the fourfold axis and emphasizing the negative charge (red) associated with the inner channel. The positively charged grooves associated with the outer surface of the octamer are also apparent (blue). These can be seen to form diagonals connecting the active sites of adjacent subunits, as shown in (b), in which the octamer is viewed from the same direction as Fig. 2[link](c) with the fourfold axis vertical.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 73| Part 1| January 2017| Pages 9-21
https://doi.org/10.1107/S2059798316019525
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