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Figure 2
Structure of human chondroadherin. (a) Tertiary structure of the hCHAD monomer. (b) Overlay of the cluster centre of the ensemble that yielded the best MR solution and the final hCHAD model (chain A). (c) Repeats 2–7; the main-chain trace illustrates the high structural regularity. (d) N-terminal caps of hCHAD, biglycan (PDB entry 2ft3) and decorin (PDB entry 1xcd); disulfide bonds are shown as sticks. (e) C-terminal caps of hCHAD and Nogo receptor; the two disulfide bonds are shown as sticks. (f) C-terminal caps of biglycan and decorin for comparison; they have a different arrangement and disulfide bonding to hCHAD. (g) Comparison of the functionally related proteins hCHAD (purple), biglycan (sand) and decorin (pink) shows very similar curvatures compared with the Nogo receptor LRR domain (green).

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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