The use of small-molecule structures to complement protein–ligand crystal structures in drug discovery

Groom, C.R.; Cole, J.C.

doi:10.1107/S2059798317000675

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 7
Systematic changes of a GPR119 agonist leading to increased solubility owing to crystal engineering. (a) Solubility 0.03 µM. (b) Self–self association of terminal groups of molecule A in the structural lattice of CSD Refcode SEMPAD. (c) Solubility 6 µM.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 73| Part 3| March 2017| Pages 240-245

https://doi.org/10.1107/S2059798317000675

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