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![[Figure 1]](ba5268fig1mag.jpg)
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Figure 1
Acoustic droplet ejection allows precise and selective targeting of crystallization droplets. (a) Schematic representation of acoustic droplet ejection for crystal soaking using the Labcyte Echo. (b) Crystallization droplets (200 nl initial volume) containing protein crystals with acoustically added solvents. Initially, 135 nl of 100 mM compound in DMSO was dispensed with the offset targeting approach to the indicated location (yellow `X'). Later, 50 nl of cryoprotecting solvent (ethylene glycol) was added at the same location. (c) The TeXRank interface showing a crystallization drop containing a single JMJD2D crystal. Clicking a location records the acoustic dispensing target for both compound-containing solvents and cryoprotectants (DMSO and ethylene glycol, respectively, in this study). The yellow `X' and xy coordinates have been added for clarity. The expanded section shows the ranked plot of crystal images. |
![[Figure 1]](ba5268fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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