Acta Cryst. (2001). E57, o1050-o1051  [ doi:10.1107/S1600536801016622 ]

(R/S)-3-(3-Methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate

L. Dupont, P. De Tullio, B. Tinant and B. Pirotte

Abstract: The crystal structure of the title compound, C₁₁H₁₆N₄O₂S·H₂O, a pancreatic B-cell selective K_ATP channel opener, reveals that that the N-alkylsulfonylguanidine moiety of the drug containing the two guanidine NH groups in the same spatial orientation (in parallel) is closely related to the N-alkylcyanoguanidine moiety of pinacidil in the solid state. The results confirm that the title drug may be considered as a hybrid compound between pinacidil and diazoxide. The crystal packing involves four hydrogen bonds which link the drug and water molecules.

Online 13 October 2001

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