Acta Cryst. (2002). E58, o148-o150  [ doi:10.1107/S1600536802000338 ]

3(S)-Acetoxymethyl-7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

A. Visnjevac, A. Avdagic and B. Kojic-Prodic

Abstract: The enantiomerically pure (S) title compound, C₁₉H₁₇ClN₂O₃, was crystallized from a 1:1 mixture of ethanol and dichloromethane. The 1,4-diazepine ring has a boat conformation with the C atom in position 3 displaced by 0.729  (4)  Å from the plane defined by the atoms in positions 1, 2, 4 and 5. A weak C-HO interaction, the most prominent feature of the crystal packing, links the molecules into infinite chains stretched along the c axis. The title compound, as well as other 1,4-benzodiazepin-2-one derivatives, are suitable precursors for the synthesis of enantiomerically pure -amino acids and their congeners.

Online 18 January 2002

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