(IUCr) Crystallography Journals Online

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Acta Cryst. (2002). E58, o812-o814 [ doi:10.1107/S1600536802011480 ]

Synthesis and absolute configuration of methyl (-)-(3R)-8-(4-bromophenyl)-7-(naphthalen-1-ylmethyl)-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylate

V. Åberg, D. Boström, A. Fischer and F. Almqvist

Abstract: The title molecule, C₂₆H₂₀BrNO₃S, contains a ring-fused 2-pyridinone framework substituted with a 4-bromo-phenyl-, a naphthalen-1-ylmethyl and a methoxycarbonyl substituent. The main goal of this work was to confirm the stereochemistry for the methoxycarbonyl substituent, which proved to be 3R. Moreover, the 4-bromophenyl substituent was shown to be rotated out of the plane of the 2-pyridinone ring, with a torsion angle of 61.2 (5)°. To allow the best packing arrangement, the naphthalen-1-ylmethyl substituent is positioned to mediate an intermolecular [pi] - [pi] interaction.

Online 12 July 2002